Bone lesions in chronic granulocytic leukaemia.

Bone lesions in chronic granulocytic leukaemia.

Radiographic abnormalities in bone are unusual during the stable phase of chronic granulocytic leukaemia (CGL). A rare situation is reported in which a patient developed three distinctive skeletal lesions simultaneously in different anatomical sites. Firstly, in both fibulae symmetrical punched out and permeative lesions were present throughout much of the shafts, being most prominent in the mi...

Leukapheresis for papilloedema in chronic granulocytic leukaemia.

Hypercalcaemia and osteolytic bone lesions in chronic lymphocytic leukaemia.

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Extensive bone marrow infarction followed by myelofibrosis in patient with Ph' positive chronic granulocytic leukaemia.

A 28-year-old man with Philadelphia chromosome positive chronic granulocytic leukaemia developed extensive bone marrow and bone infarction which was associated with anaemia and thrombocytopenia. He survived 20 months from the first symptoms of bone marrow infarction; during this time he developed myelofibrosis and osteosclerosis followed by blastic transformation. Extensive bone marrow infarcti...

Histamine release reaction of basophils in chronic granulocytic leukaemia

Basophils possess membrane bound IgE molecules, and immunological activation leads to a secretary process with cell degranulation and histamine release. Heterologous anti IgE, concanavaline A, and phytohaemagglutinin are potent non-cytotoxic releasing agents. They operate by a mechanism similar to that ofimmunological activation. Heavy water is not a histamine releasing inducer but it increases...